Harvest is one of the best refills because you pick first, pulling the strongest card in the reveal straight into your hand. Play it when your hand is thin or you've just been stripped and need Attacks or Defense fast. Lords and Loyalists in a big lobby love it to rebuild card economy — but it also arms the Rebels, so hold it if the reveal helps enemies more than you.
Pairs with heroes who devour cards: กวนอู turns every red card you grab into an Attack, and เตียวหุย dumps the freshly refilled hand into an unlimited barrage — brutal alongside a หน้าไม้ (Repeating Crossbow). It's also the cleanest way to rebuild after ปล้น or ทำลาย empties you, then unleash your offense.
ปัดป้อง (Negate) is the cleanest answer — cancel the whole Harvest and deny the entire table its draw, including the caster's coveted first pick. If a Rebel or Traitor is refilling to close out the game, don't hesitate. But remember you gain a free card too, so if the reveal doesn't arm the enemy much, just let it resolve and take yours.